The kyphoscoliosis (ky) mouse is deficient in hypertrophic responses and is caused by a mutation in a novel muscle-specific protein.

Blanco, G; Coulton, G R; Biggin, A; Grainge, C; Moss, J; Barrett, M; Berquin, A; Maréchal, G; Skynner, M; van Mier, P; Nikitopoulou, A; Kraus, M; Ponting, C P; Mason, R M; Brown, S D

Blanco, G; Coulton, G R; Biggin, A; Grainge, C; Moss, J; Barrett, M; Berquin, A; Maréchal, G; Skynner, M; van Mier, P; Nikitopoulou, A; Kraus, M; Ponting, C P; Mason, R M; Brown, S D.

Affiliation

Blanco G; MRC Mammalian Genetics Unit and UK Mouse Genome Centre, Harwell, Oxon OX11 ORD, UK. g.blanco@har.mrc.ac.uk

Hum Mol Genet ; 10(1): 9-16, 2001 Jan 01.

Article in En | MEDLINE | ID: mdl-11136708

Subject(s)

Muscles/metabolism; Muscular Diseases/genetics; Mutation; Scoliosis/genetics; Amino Acid Sequence; Animals; Blotting, Northern; Cloning, Molecular; Disease Models, Animal; Homozygote; Hypertrophy; Immunohistochemistry; Mice; Microscopy, Confocal; Microscopy, Video; Models, Genetic; Molecular Sequence Data; Myosin Heavy Chains/chemistry; Myosin Heavy Chains/genetics; Neuromuscular Junction/abnormalities; Protein Isoforms; Radiography; Reverse Transcriptase Polymerase Chain Reaction; Scoliosis/diagnostic imaging; Scoliosis/metabolism; Sequence Homology, Amino Acid; Tissue Distribution; Transglutaminases/chemistry

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Collection: 01-internacional Database: MEDLINE Main subject: Scoliosis / Muscles / Muscular Diseases / Mutation Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2001 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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