Adrenomedullin receptors in rat choroid plexus.
Neurosci Lett
; 297(3): 167-70, 2001 Jan 19.
Article
in En
| MEDLINE
| ID: mdl-11137754
ABSTRACT
To characterize transmembrane signaling of adrenomedullin (AM) in the choroid plexus, we studied the effects of AM on cyclic AMP (cAMP) and cyclic GMP (cGMP) levels as well as expression of mRNA for AM receptor in the rat choroid plexus slices. AM or calcitonin gene-related peptide (CGRP) increased cAMP (but not cGMP) level in a concentration-dependent manner, with AM being much more potently than CGRP. AM mRNA as well as calcitonin-receptor-like receptor mRNA and receptor-activity-modifying protein 2 mRNA, were highly expressed in the choroid plexus. Our biochemical and pharmacological studies may raise the possibility that choroid plexus secretes AM into the cerebrospinal fluid, and AM regulates choroid plexus function in an autocrine/paracrine manner via acting on AM-specific receptors.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Choroid Plexus
/
Receptors, Peptide
Limits:
Animals
Language:
En
Journal:
Neurosci Lett
Year:
2001
Document type:
Article
Affiliation country:
Japan
Country of publication:
IE
/
IRELAND
/
IRLANDA