Design and synthesis of new orally active nonpeptidic inhibitors of human neutrophil elastase.

Ohmoto, K; Yamamoto, T; Horiuchi, T; Imanishi, H; Odagaki, Y; Kawabata, K; Sekioka, T; Hirota, Y; Matsuoka, S; Nakai, H; Toda, M; Cheronis, J C; Spruce, L W; Gyorkos, A; Wieczorek, M

Ohmoto, K; Yamamoto, T; Horiuchi, T; Imanishi, H; Odagaki, Y; Kawabata, K; Sekioka, T; Hirota, Y; Matsuoka, S; Nakai, H; Toda, M; Cheronis, J C; Spruce, L W; Gyorkos, A; Wieczorek, M.

Affiliation

Ohmoto K; Gonex, Inc., Colorado State University, ARBL, Ft. Collins, Colorado 80523-1683, USA.

J Med Chem ; 43(26): 4927-9, 2000 Dec 28.

Article in En | MEDLINE | ID: mdl-11150162

Subject(s)

Enzyme Inhibitors/chemical synthesis; Leukocyte Elastase/antagonists & inhibitors; Oxadiazoles/chemical synthesis; Pyrimidinones/chemical synthesis; Administration, Oral; Animals; Crystallography, X-Ray; Dogs; Drug Design; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology; Haplorhini; Humans; Oxadiazoles/chemistry; Oxadiazoles/pharmacology; Pyrimidinones/chemistry; Pyrimidinones/pharmacology; Rats; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Oxadiazoles / Pyrimidinones / Leukocyte Elastase / Enzyme Inhibitors Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2000 Document type: Article Affiliation country: United States Country of publication: United States

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