Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor.

Gerlach, L O; Skerlj, R T; Bridger, G J; Schwartz, T W

Gerlach, L O; Skerlj, R T; Bridger, G J; Schwartz, T W.

Affiliation

Gerlach LO; Laboratory for Molecular Pharmacology, University of Copenhagen, Panum Institute, DK-2200 Copenhagen, Denmark.

J Biol Chem ; 276(17): 14153-60, 2001 Apr 27.

Article in En | MEDLINE | ID: mdl-11154697

Subject(s)

Receptors, CXCR4/chemistry; Receptors, CXCR4/metabolism; Amino Acid Sequence; Animals; Anti-HIV Agents/pharmacology; Antiviral Agents/pharmacology; Asparagine/chemistry; Aspartic Acid/chemistry; Benzylamines; Binding, Competitive; COS Cells; Chemokine CXCL12; Chemokines, CXC/chemistry; Cyclams; DNA, Complementary/metabolism; Heterocyclic Compounds/chemistry; Humans; Inhibitory Concentration 50; Kinetics; Ligands; Linear Models; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Receptors, CXCR4/genetics; Transfection

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Collection: 01-internacional Database: MEDLINE Main subject: Receptors, CXCR4 Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2001 Document type: Article Affiliation country: Denmark Country of publication: United States

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