Pharmacokinetic Interaction between amprenavir and rifabutin or rifampin in healthy males.

Polk, R E; Brophy, D F; Israel, D S; Patron, R; Sadler, B M; Chittick, G E; Symonds, W T; Lou, Y; Kristoff, D; Stein, D S

Polk, R E; Brophy, D F; Israel, D S; Patron, R; Sadler, B M; Chittick, G E; Symonds, W T; Lou, Y; Kristoff, D; Stein, D S.

Affiliation

Polk RE; School of Pharmacy, Virginia Commonwealth University/Medical College of Virginia Campus, Richmond, Virginia 23298-0533, USA.

Antimicrob Agents Chemother ; 45(2): 502-8, 2001 Feb.

Article in En | MEDLINE | ID: mdl-11158747

Subject(s)

Antibiotics, Antitubercular/pharmacokinetics; Rifabutin/pharmacokinetics; Rifampin/pharmacokinetics; Sulfonamides/pharmacokinetics; Adolescent; Adult; Anti-Bacterial Agents; Biotransformation; Breath Tests; Carbamates; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System/genetics; Cytochrome P-450 Enzyme System/metabolism; Dealkylation; Drug Interactions; Erythromycin; Furans; Humans; Male; Middle Aged; Mixed Function Oxygenases/antagonists & inhibitors; Mixed Function Oxygenases/genetics; Mixed Function Oxygenases/metabolism; Sulfonamides/blood; Sulfonamides/urine

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rifampin / Sulfonamides / Rifabutin / Antibiotics, Antitubercular Type of study: Clinical_trials / Prognostic_studies Limits: Adolescent / Adult / Humans / Male / Middle aged Language: En Journal: Antimicrob Agents Chemother Year: 2001 Document type: Article Affiliation country: United States Country of publication: United States

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