Use-dependent effects of amyloidogenic fragments of (beta)-amyloid precursor protein on synaptic plasticity in rat hippocampus in vivo.

Kim, J H; Anwyl, R; Suh, Y H; Djamgoz, M B; Rowan, M J

Kim, J H; Anwyl, R; Suh, Y H; Djamgoz, M B; Rowan, M J.

Affiliation

Kim JH; Departments of Pharmacology, Trinity College, Dublin 2, Ireland.

J Neurosci ; 21(4): 1327-33, 2001 Feb 15.

Article in En | MEDLINE | ID: mdl-11160403

Subject(s)

Amyloid beta-Protein Precursor/metabolism; Hippocampus/drug effects; Hippocampus/metabolism; Neuronal Plasticity/drug effects; Peptide Fragments/administration & dosage; Amyloid/biosynthesis; Amyloid beta-Peptides/administration & dosage; Amyloid beta-Protein Precursor/administration & dosage; Animals; Dose-Response Relationship, Drug; Electric Stimulation/methods; Electrodes, Implanted; Excitatory Amino Acid Antagonists/pharmacology; Excitatory Postsynaptic Potentials/drug effects; Injections, Intraventricular; Long-Term Potentiation/drug effects; Male; Neural Inhibition/drug effects; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Amyloid beta-Protein Precursor / Hippocampus / Neuronal Plasticity Limits: Animals Language: En Journal: J Neurosci Year: 2001 Document type: Article Affiliation country: Ireland

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