The sulfonylurea glimepiride regulates intracellular routing of the insulin-receptor complexes through their interaction with specific protein kinase C isoforms.

Hribal, M L; D'Alfonso, R; Giovannone, B; Lauro, D; Liu, Y Y; Borboni, P; Federici, M; Lauro, R; Sesti, G

Hribal, M L; D'Alfonso, R; Giovannone, B; Lauro, D; Liu, Y Y; Borboni, P; Federici, M; Lauro, R; Sesti, G.

Affiliation

Hribal ML; Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome-Tor Vergata, Rome-Italy.

Mol Pharmacol ; 59(2): 322-30, 2001 Feb.

Article in En | MEDLINE | ID: mdl-11160869

Subject(s)

Isoenzymes/metabolism; Protein Kinase C/metabolism; Receptor, Insulin/metabolism; Sulfonylurea Compounds/pharmacology; Down-Regulation; Enzyme Inhibitors/pharmacology; Glucose/metabolism; Glycogen/metabolism; Humans; Hypoglycemic Agents/pharmacology; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Phosphoproteins/metabolism; Phosphorylation/drug effects; Protein Kinase C/antagonists & inhibitors; Protein Kinase C/classification; Protein-Tyrosine Kinases/metabolism; Receptor, Insulin/drug effects; Tumor Cells, Cultured; Tyrosine/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Sulfonylurea Compounds / Protein Kinase C / Receptor, Insulin / Isoenzymes Limits: Humans Language: En Journal: Mol Pharmacol Year: 2001 Document type: Article

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