Prophylaxis of radiogenic sialadenitis and mucositis by coumarin/troxerutine in patients with head and neck cancer--a prospective,randomized, placebo-controlled, double-blind study.
Br J Oral Maxillofac Surg
; 39(1): 34-9, 2001 Feb.
Article
in En
| MEDLINE
| ID: mdl-11178853
ABSTRACT
OBJECTIVE:
To study the efficacy of coumarin/troxerutine for the protection of salivary glands and mucosa during irradiation.DESIGN:
Prospective, randomized, placebo-controlled, double-blind trial.SETTING:
University hospital, Germany. PATIENTS 48 patients who had radiotherapy to the head and neck. MAIN OUTCOMEMEASURES:
Salivary gland scintigraphy and acute side-effects of radiotherapy (Radiation Therapy Oncology Group (RTOG) score).RESULTS:
23 patients (11 experimental, 12 placebo) completed the study. The global efficacy measure combining scintigraphy and RTOG score favoured the experimental arm (P=0.07). The RTOG score showed significantly fewer acute side-effects of radiation in the experimental arm (P<0.05).CONCLUSION:
The results suggest that coumarin/troxerutine have a favourable effect in the treatment of radiogenic sialadenitis and mucositis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Radiation Injuries
/
Radiation-Protective Agents
/
Sialadenitis
/
Cranial Irradiation
/
Coumarins
/
Hydroxyethylrutoside
Type of study:
Clinical_trials
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Br J Oral Maxillofac Surg
Year:
2001
Document type:
Article
Affiliation country:
Germany