Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition.

Chen, Z; Karaplis, A C; Ackerman, S L; Pogribny, I P; Melnyk, S; Lussier-Cacan, S; Chen, M F; Pai, A; John, S W; Smith, R S; Bottiglieri, T; Bagley, P; Selhub, J; Rudnicki, M A; James, S J; Rozen, R

Chen, Z; Karaplis, A C; Ackerman, S L; Pogribny, I P; Melnyk, S; Lussier-Cacan, S; Chen, M F; Pai, A; John, S W; Smith, R S; Bottiglieri, T; Bagley, P; Selhub, J; Rudnicki, M A; James, S J; Rozen, R.

Affiliation

Chen Z; Departments of Biology, Human Genetics and Pediatrics, Department of Medicine, Department of Pathology, McGill University, Montreal, Quebec H3A 1B1, Canada.

Hum Mol Genet ; 10(5): 433-43, 2001 Mar 01.

Article in En | MEDLINE | ID: mdl-11181567

Subject(s)

Aorta/metabolism; Hyperhomocysteinemia/genetics; Lipid Metabolism; Nervous System/pathology; Oxidoreductases Acting on CH-NH Group Donors/physiology; Animals; Base Sequence; DNA Methylation; DNA Primers; Heterozygote; Homozygote; Hyperhomocysteinemia/enzymology; Hyperhomocysteinemia/pathology; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Knockout; Oxidoreductases Acting on CH-NH Group Donors/genetics; Oxidoreductases Acting on CH-NH Group Donors/metabolism; Phenotype; Reverse Transcriptase Polymerase Chain Reaction

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Aorta / Hyperhomocysteinemia / Lipid Metabolism / Oxidoreductases Acting on CH-NH Group Donors / Nervous System Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2001 Document type: Article Affiliation country: Canada Country of publication: United kingdom

Search on Google

Add to My VHL

XML

PubMed Links