Startle responses, heart rate, and temperature in 5-HT1B receptor knockout mice.
Neuroreport
; 11(18): 4097-102, 2000 Dec 18.
Article
in En
| MEDLINE
| ID: mdl-11192635
ABSTRACT
Relative to wildtype mice, mice lacking 5-HT1B receptors (5-HT1B KO) exhibit exaggerated heart rate and body temperature responses to environmental stimuli. In contrast, acoustic startle reactivity is reduced in 5-HT1B KO mice. We combined heart rate and temperature measurement with startle response paradigms in order to elucidate this apparent contradiction. Habituation and footshock-induced sensitization paradigms modulate startle reactivity. Reduced startle reactivity and unaltered habituation in 5-HT1B KO mice were replicated. Heart rate and temperature were unaffected by startle stimuli, but increased markedly in response to transportation and handling procedures. Footshocks caused a mild startle-sensitization and tachycardia in both genotypes. The physiological hyper-reactivity in 5-HT1B KO mice is a subtle phenotypic difference that contrasts with the phenotypic decrease in startle reactivity.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Reflex, Startle
/
Body Temperature
/
Brain
/
Receptors, Serotonin
/
Mice, Knockout
/
Heart Rate
Limits:
Animals
Language:
En
Journal:
Neuroreport
Journal subject:
NEUROLOGIA
Year:
2000
Document type:
Article
Affiliation country:
Netherlands