Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia.

Ferrara, F F; Fazi, F; Bianchini, A; Padula, F; Gelmetti, V; Minucci, S; Mancini, M; Pelicci, P G; Lo Coco, F; Nervi, C

Ferrara, F F; Fazi, F; Bianchini, A; Padula, F; Gelmetti, V; Minucci, S; Mancini, M; Pelicci, P G; Lo Coco, F; Nervi, C.

Affiliation

Ferrara FF; Department of Histology and Medical Embryology, University of Rome La Sapienza, Italy.

Cancer Res ; 61(1): 2-7, 2001 Jan 01.

Article in En | MEDLINE | ID: mdl-11196162

Subject(s)

Antineoplastic Agents/pharmacology; Histone Deacetylase Inhibitors; Leukemia, Myeloid, Acute/enzymology; Leukemia, Myeloid, Acute/pathology; Leukemia, Myelomonocytic, Acute/enzymology; Leukemia, Myelomonocytic, Acute/pathology; Signal Transduction/drug effects; Tretinoin/pharmacology; Acetylation; Cell Differentiation/drug effects; Cell Differentiation/physiology; Core Binding Factor Alpha 2 Subunit; Enzyme Inhibitors/pharmacology; Gene Expression Regulation, Leukemic/drug effects; Histone Deacetylases/physiology; Histones/metabolism; Humans; Hydroxamic Acids/pharmacology; Leukemia, Myeloid, Acute/genetics; Leukemia, Myelomonocytic, Acute/genetics; Oncogene Proteins, Fusion/biosynthesis; Oncogene Proteins, Fusion/genetics; RUNX1 Translocation Partner 1 Protein; Signal Transduction/physiology; Transcription Factors/biosynthesis; Transcription Factors/genetics; Transcriptional Activation/drug effects; Transcriptional Activation/physiology; Tretinoin/physiology; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Tretinoin / Leukemia, Myelomonocytic, Acute / Leukemia, Myeloid, Acute / Signal Transduction / Histone Deacetylase Inhibitors / Antineoplastic Agents Limits: Humans Language: En Journal: Cancer Res Year: 2001 Document type: Article Affiliation country: Italy Country of publication: United States

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