Granulocyte/macrophage-colony stimulating factor produced by recombinant avian poxviruses enriches the regional lymph nodes with antigen-presenting cells and acts as an immunoadjuvant.

Kass, E; Panicali, D L; Mazzara, G; Schlom, J; Greiner, J W

Kass, E; Panicali, D L; Mazzara, G; Schlom, J; Greiner, J W.

Affiliation

Kass E; Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.

Cancer Res ; 61(1): 206-14, 2001 Jan 01.

Article in En | MEDLINE | ID: mdl-11196163

Subject(s)

Antigen-Presenting Cells/immunology; Cancer Vaccines/immunology; Granulocyte-Macrophage Colony-Stimulating Factor/immunology; Lymph Nodes/immunology; Adjuvants, Immunologic/genetics; Adjuvants, Immunologic/pharmacology; Animals; Antibodies, Neoplasm/biosynthesis; Antibodies, Neoplasm/blood; Avipoxvirus/genetics; Cancer Vaccines/genetics; Carcinoembryonic Antigen/genetics; Carcinoembryonic Antigen/immunology; Chick Embryo; Epitopes, T-Lymphocyte/immunology; Female; Genetic Vectors/genetics; Granulocyte-Macrophage Colony-Stimulating Factor/biosynthesis; Granulocyte-Macrophage Colony-Stimulating Factor/genetics; Humans; Immunoglobulin G/biosynthesis; Immunoglobulin G/blood; Lymph Nodes/cytology; Lymphocyte Activation/immunology; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasms, Experimental/immunology; Neoplasms, Experimental/therapy; Recombinant Proteins; T-Lymphocytes/immunology; Vaccines, Synthetic/genetics; Vaccines, Synthetic/immunology

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Collection: 01-internacional Database: MEDLINE Main subject: Granulocyte-Macrophage Colony-Stimulating Factor / Cancer Vaccines / Lymph Nodes / Antigen-Presenting Cells Limits: Animals / Female / Humans / Male Language: En Journal: Cancer Res Year: 2001 Document type: Article Affiliation country: United States Country of publication: United States

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