[Treatment of experimental corneal injuries by dioxidine and urotropin solutions]. / Lechenie travm rogovitsy rastvorami dioksidina i urotropina v éksperimente.
Vestn Oftalmol
; 116(6): 20-3, 2000.
Article
in Ru
| MEDLINE
| ID: mdl-11196208
ABSTRACT
The efficiency of 1% dioxidine and 5% urotropin solutions in suppurative penetrating corneal wounds was studied in 2 experimental series on 54 rabbits. In series A toxic effects of these drugs on eyeball tissues were studied on 6 rats, in series B drug effects were studied on a model of suppurative penetrating corneal wounds. A 21-day course of therapy with these drugs (instillations and subconjunctival parabulbar injections) caused no toxic changes in ocular tissues. Therapy with 1% dioxidine and 5% urotropin accelerated clinical cure by 4-6 days in comparison with other methods of treatment. Clinical cure was observed 3-5 days sooner after combined use of both drugs in comparison with their individual application, during during combined use their antibacterial effect was synergistic. Hence, a combination of 1% dioxidine and 5% urotropin solutions is an effective method for treating suppurative penetrating wounds of the cornea.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quinoxalines
/
Eye Injuries, Penetrating
/
Corneal Injuries
/
Methenamine
/
Anti-Bacterial Agents
Limits:
Animals
Language:
Ru
Journal:
Vestn Oftalmol
Year:
2000
Document type:
Article