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[Visual field changes secondary to vigabatrin treatment]. / Alteraciones de los campos visuales secundarias al tratamiento con vigabatrina.
Mauri-Llerda, J A; Iñiguez, C; Tejero-Juste, C; Santos-Lasaosa, S; Escalza-Cortina, I; Ascaso-Puyuelo, J; Abad-Alegría, F; Morales-Asín, F.
Affiliation
  • Mauri-Llerda JA; Servicio de Neurología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España. jamauri@retemail.es
Rev Neurol ; 31(12): 1104-8, 2000.
Article in Es | MEDLINE | ID: mdl-11205539
INTRODUCTION: Vigabatrin is an effective antiepileptic drug for treatment of partial crises with or without generalization. It acts by increasing GABA levels by irreversible inhibition of the enzyme GABA-transaminase. In recent years there have been several reports published on the appearance of alterations of the visual fields of patients treated with this drug. OBJECTIVE: To study the prevalence and characteristics of the visual field changes associated with vigabatrin treatment in an adult epilepsy clinic. PATIENTS AND METHODS: Ophthalmological examination, consisting of questions about eye symptoms, study of the fundus oculi, Humphrey-type campimetry, protocol 30-2, visual evoked potentials and electroretinogram were done on a group of 10 patients on long-term vigabatrin treatment. RESULTS: Six of the ten patients (60%) had campimetric alterations, which were serious in two cases (20%). Only the two patients with severe field defects complained of sight changes when questioned and their complaints were mainly of repeatedly bumping into things. In two patients (20%) there was pallor of the optic nerve. In both cases, the patients with severe field defects showed alterations on the electroretinogram. Visual evoked potentials were normal in all cases. CONCLUSIONS: There is a very high prevalence of visual field defects in patients on long-term treatment with vigabatrin. Clinical ophthalmological signs are not usually seen until advanced stages. Pallor of the optic nerve was seen in a group of patients. It is very important that serial campimetric studies are done for early detection of such alterations.
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Collection: 01-internacional Database: MEDLINE Main subject: Vision Disorders / Visual Fields / Vigabatrin / Anticonvulsants Type of study: Diagnostic_studies / Guideline / Prevalence_studies / Risk_factors_studies / Screening_studies Limits: Adult / Female / Humans / Male / Middle aged Language: Es Journal: Rev Neurol Year: 2000 Document type: Article Country of publication: Spain
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Collection: 01-internacional Database: MEDLINE Main subject: Vision Disorders / Visual Fields / Vigabatrin / Anticonvulsants Type of study: Diagnostic_studies / Guideline / Prevalence_studies / Risk_factors_studies / Screening_studies Limits: Adult / Female / Humans / Male / Middle aged Language: Es Journal: Rev Neurol Year: 2000 Document type: Article Country of publication: Spain