Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5'-polyphosphates.
Bioorg Med Chem Lett
; 11(2): 157-60, 2001 Jan 22.
Article
in En
| MEDLINE
| ID: mdl-11206448
ABSTRACT
A series of dinucleoside 5-polyphosphates UpnU (n = 2-7) was synthesized. Their relative potencies as agonists at the G-protein-coupled receptors P2Y1, P2Y2, P2Y4, and P2Y6 were determined by intracellular calcium measurements using fluorescent imaging techniques. The correlation of phosphate chain length to activities at these receptors is discussed.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Uracil Nucleotides
/
Dinucleoside Phosphates
/
Purinergic P2 Receptor Agonists
Limits:
Humans
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2001
Document type:
Article
Affiliation country:
United States