PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model.

Weng, L P; Smith, W M; Brown, J L; Eng, C

Weng, L P; Smith, W M; Brown, J L; Eng, C.

Affiliation

Weng LP; Clinical Cancer Genetics Program, Comprehensive Cancer Center, Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA.

Hum Mol Genet ; 10(6): 605-16, 2001 Mar 15.

Article in En | MEDLINE | ID: mdl-11230180

Subject(s)

Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Breast Neoplasms/enzymology; Insulin/pharmacology; Phosphoproteins/metabolism; Phosphoric Monoester Hydrolases/physiology; Tumor Suppressor Proteins; Breast Neoplasms/metabolism; Cell Division/drug effects; Drug Interactions; Enzyme Inhibitors/pharmacology; GRB2 Adaptor Protein; Humans; Insulin Receptor Substrate Proteins; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors; Mitogen-Activated Protein Kinase Kinases/metabolism; Mitogen-Activated Protein Kinases/metabolism; PTEN Phosphohydrolase; Phosphoproteins/chemistry; Phosphoric Monoester Hydrolases/genetics; Phosphorylation; Proteins/metabolism; Receptor, Insulin/metabolism; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Phosphoproteins / Breast Neoplasms / Phosphoric Monoester Hydrolases / Tumor Suppressor Proteins / Adaptor Proteins, Vesicular Transport / Adaptor Proteins, Signal Transducing / Insulin Type of study: Prognostic_studies Limits: Humans Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2001 Document type: Article Affiliation country: United States Country of publication: United kingdom

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