Signal transduction through the Ras/Erk pathway is essential for the mycoestrogen zearalenone-induced cell-cycle progression in MCF-7 cells.

Ahamed, S; Foster, J S; Bukovsky, A; Wimalasena, J

Ahamed, S; Foster, J S; Bukovsky, A; Wimalasena, J.

Affiliation

Ahamed S; Department of Obstetrics and Gynecology, Graduate School of Medicine, University of Tennessee, Knoxville, Tennessee 37920, USA.

Mol Carcinog ; 30(2): 88-98, 2001 Feb.

Article in En | MEDLINE | ID: mdl-11241756

Subject(s)

Breast Neoplasms/pathology; Cell Cycle Proteins; Cell Cycle/drug effects; Estrogens, Non-Steroidal/pharmacology; Mitogen-Activated Protein Kinases/metabolism; Proto-Oncogene Proteins p21(ras)/metabolism; Signal Transduction; Tumor Suppressor Proteins; Zearalenone/pharmacology; Adenoviridae/genetics; Annexin A5/metabolism; Blotting, Northern; Blotting, Western; Breast Neoplasms/metabolism; Bromodeoxyuridine; Cell Survival/drug effects; Cyclin D1/metabolism; Cyclin-Dependent Kinase Inhibitor p27; Down-Regulation; Female; Flow Cytometry; Formazans; Genes, myc/drug effects; Humans; Luciferases/metabolism; Microtubule-Associated Proteins/antagonists & inhibitors; Mitosis/drug effects; Phosphorylation; Tetrazolium Salts; Tumor Cells, Cultured/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Zearalenone / Breast Neoplasms / Signal Transduction / Cell Cycle / Proto-Oncogene Proteins p21(ras) / Cell Cycle Proteins / Mitogen-Activated Protein Kinases / Tumor Suppressor Proteins / Estrogens, Non-Steroidal Limits: Female / Humans Language: En Journal: Mol Carcinog Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2001 Document type: Article Affiliation country: United States Country of publication: United States

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