Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells.

Tan, C; Costello, P; Sanghera, J; Dominguez, D; Baulida, J; de Herreros, A G; Dedhar, S

Tan, C; Costello, P; Sanghera, J; Dominguez, D; Baulida, J; de Herreros, A G; Dedhar, S.

Affiliation

Tan C; BC Cancer Agency and Jack Bell Research Centre, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada.

Oncogene ; 20(1): 133-40, 2001 Jan 04.

Article in En | MEDLINE | ID: mdl-11244511

Subject(s)

Cadherins/physiology; Colonic Neoplasms/metabolism; Cytoskeletal Proteins/antagonists & inhibitors; Cytoskeletal Proteins/genetics; DNA-Binding Proteins/antagonists & inhibitors; Protein Serine-Threonine Kinases/antagonists & inhibitors; Trans-Activators; Transcription Factors/antagonists & inhibitors; Transcription, Genetic; Adenomatous Polyposis Coli/enzymology; Adenomatous Polyposis Coli/genetics; Adenomatous Polyposis Coli Protein; Cadherins/genetics; Cadherins/metabolism; Colonic Neoplasms/genetics; Cytoskeletal Proteins/deficiency; Cytoskeletal Proteins/physiology; DNA-Binding Proteins/genetics; DNA-Binding Proteins/physiology; Genes, APC; Humans; Integrins/physiology; Lymphoid Enhancer-Binding Factor 1; Neoplasm Proteins/deficiency; Neoplasm Proteins/genetics; Protein Serine-Threonine Kinases/genetics; Protein Serine-Threonine Kinases/physiology; Repressor Proteins/antagonists & inhibitors; Repressor Proteins/genetics; Repressor Proteins/physiology; Snail Family Transcription Factors; Transcription Factors/genetics; Transcription Factors/physiology; Tumor Cells, Cultured; beta Catenin

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Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Transcription, Genetic / Cadherins / Trans-Activators / Protein Serine-Threonine Kinases / Colonic Neoplasms / Cytoskeletal Proteins / DNA-Binding Proteins Limits: Humans Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2001 Document type: Article Affiliation country: Canada Country of publication: United kingdom

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