Detection of regional temporal abnormalities in left ventricular function during acute myocardial ischemia.
Am J Physiol Heart Circ Physiol
; 280(4): H1770-81, 2001 Apr.
Article
in En
| MEDLINE
| ID: mdl-11247791
Echocardiographic diagnosis of myocardial ischemia is based on visualizing hypokinesis, which occurs late in the ischemic cascade. We hypothesized that temporal changes in endocardial motion may constitute sensitive early markers of ischemia. Two protocols were performed in 19 anesthetized pigs. Protocol 1 included 54 intracoronary balloon occlusions. Transthoracic images were acquired at baseline and every 15 s during 5 min of occlusion and reperfusion. In protocol 2, ischemia was induced in 12 animals by use of graded dobutamine infusion, after creating significant partial occlusions without a resting wall motion abnormality. Systolic and diastolic endocardial motion was color encoded using color kinesis and analyzed using custom software. All ischemic episodes caused detectable and reversible changes. The earliest sign of ischemia was tardokinesis in 31/54 occlusions, whereas hypokinesis appeared first in 23/54 cases. Dobutamine-induced ischemia caused tardokinesis first in 9/12 and hypokinesis in 3/12 animals. Reversible ischemic changes in regional left ventricular performance can be objectively detected using analysis of echocardiographic images and will likely improve the early noninvasive diagnosis of acute ischemia.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ventricular Function, Left
/
Myocardial Ischemia
/
Ventricular Dysfunction, Left
/
Hemodynamics
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Guideline
Limits:
Animals
Language:
En
Journal:
Am J Physiol Heart Circ Physiol
Journal subject:
CARDIOLOGIA
/
FISIOLOGIA
Year:
2001
Document type:
Article
Affiliation country:
United States
Country of publication:
United States