Omapatrilat, a dual angiotensin-converting enzyme and neutral endopeptidase inhibitor, prevents fatty streak deposit in apolipoprotein E-deficient mice.

Arnal, J F; Castano, C; Maupas, E; Mugniot, A; Darblade, B; Gourdy, P; Michel, J B; Bayard, F

Arnal, J F; Castano, C; Maupas, E; Mugniot, A; Darblade, B; Gourdy, P; Michel, J B; Bayard, F.

Affiliation

Arnal JF; INSERM U397 et laboratoire de Physiologie, Institut L. Bugnard, CHU Rangueil, 31403, Toulouse, France. arnal@rangueil.inserm.fr

Atherosclerosis ; 155(2): 291-5, 2001 Apr.

Article in En | MEDLINE | ID: mdl-11254898

Subject(s)

Angiotensin-Converting Enzyme Inhibitors/therapeutic use; Apolipoproteins E/deficiency; Arteriosclerosis/prevention & control; Neprilysin/antagonists & inhibitors; Protease Inhibitors/therapeutic use; Pyridines/therapeutic use; Thiazepines/therapeutic use; Angiotensin-Converting Enzyme Inhibitors/pharmacology; Animals; Apolipoproteins E/genetics; Apolipoproteins E/physiology; Arteriosclerosis/enzymology; Atrial Natriuretic Factor/metabolism; Body Weight/drug effects; Bradykinin/metabolism; Cholesterol/blood; Cholesterol, HDL/blood; Drug Evaluation, Preclinical; Indans/pharmacology; Indans/therapeutic use; Male; Mice; Mice, Knockout; Propionates/pharmacology; Propionates/therapeutic use; Protease Inhibitors/pharmacology; Pyridines/pharmacology; Substance P/metabolism; Thiazepines/pharmacology; Triglycerides/blood

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Collection: 01-internacional Database: MEDLINE Main subject: Apolipoproteins E / Arteriosclerosis / Protease Inhibitors / Pyridines / Thiazepines / Angiotensin-Converting Enzyme Inhibitors / Neprilysin Type of study: Prognostic_studies Limits: Animals Language: En Journal: Atherosclerosis Year: 2001 Document type: Article Affiliation country: France Country of publication: Ireland

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