Multiple mutations modulate the function of dihydrofolate reductase in trimethoprim-resistant Streptococcus pneumoniae.

Maskell, J P; Sefton, A M; Hall, L M

Maskell, J P; Sefton, A M; Hall, L M.

Affiliation

Maskell JP; Department of Medical Microbiology, St. Bartholomew's and the Royal London School of Medicine and Dentistry, London E1 2AD, United Kingdom. J.Maskell@mds.ac.uk

Antimicrob Agents Chemother ; 45(4): 1104-8, 2001 Apr.

Article in En | MEDLINE | ID: mdl-11257022

Subject(s)

Anti-Infective Agents, Urinary/pharmacology; Mutation; Streptococcus pneumoniae/drug effects; Tetrahydrofolate Dehydrogenase/genetics; Trimethoprim/pharmacology; Amino Acid Sequence; Amino Acid Substitution; Base Sequence; Drug Resistance, Microbial; Genes, Bacterial; Humans; Inhibitory Concentration 50; Kinetics; Microbial Sensitivity Tests; Pneumococcal Infections/microbiology; Streptococcus pneumoniae/enzymology; Streptococcus pneumoniae/genetics; Tetrahydrofolate Dehydrogenase/metabolism; Transformation, Bacterial

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Streptococcus pneumoniae / Tetrahydrofolate Dehydrogenase / Trimethoprim / Anti-Infective Agents, Urinary / Mutation Limits: Humans Language: En Journal: Antimicrob Agents Chemother Year: 2001 Document type: Article Affiliation country: United kingdom Country of publication: United States

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