Ellagic acid inhibited 2-aminofluorene and p-aminobenzoic acid acetylation by mononuclear leucocytes from Sprague-Dawley rats.
Cytobios
; 104(406): 107-17, 2001.
Article
in En
| MEDLINE
| ID: mdl-11258539
ABSTRACT
Following exposure of rats to the arylamine carcinogen 2-aminofluorene, DNA-carcinogen adducts were found in the liver and bladder target tissues, and also in circulating leucocytes. This work investigated the effect of ellagic acid on arylamine (2-aminofluorene and p-aminobenzoic acid) acetylations in rat leucocytes. Evidence is presented that rat mononuclear leucocytes are capable of acetylating 2-aminofluorene and p-aminobenzoic acid. Both lymphocytes and monocytes were able to acetylate arylamines during 18 h of culture. Cultured lymphocytes produced about twice as much N-acetyl-2-aminofluorene from 2-aminofluorene and 2.2-fold as much N-acetyl-p-aminobenzoic acid from p-aminobenzoic acid as monocytes. After cotreatment with ellagic acid the lymphocyte and monocyte cultures indicated that ellagic acid reduced 2-aminofluorene acetylation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arylamine N-Acetyltransferase
/
4-Aminobenzoic Acid
/
Ellagic Acid
/
Fluorenes
/
Leukocytes
Limits:
Animals
Language:
En
Journal:
Cytobios
Year:
2001
Document type:
Article
Affiliation country:
China