Herpes simplex virus vector-mediated expression of Bcl-2 protects spinal motor neurons from degeneration following root avulsion.

Yamada, M; Natsume, A; Mata, M; Oligino, T; Goss, J; Glorioso, J; Fink, D J

Yamada, M; Natsume, A; Mata, M; Oligino, T; Goss, J; Glorioso, J; Fink, D J.

Affiliation

Yamada M; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.

Exp Neurol ; 168(2): 225-30, 2001 Apr.

Article in En | MEDLINE | ID: mdl-11259110

Subject(s)

Anterior Horn Cells/metabolism; Genetic Vectors/therapeutic use; Motor Neurons/metabolism; Nerve Degeneration/prevention & control; Proto-Oncogene Proteins c-bcl-2/metabolism; Radiculopathy/metabolism; Animals; Anterior Horn Cells/drug effects; Cell Death/drug effects; Cell Death/physiology; Choline O-Acetyltransferase/metabolism; Genetic Vectors/metabolism; Humans; Male; Motor Neurons/drug effects; Motor Neurons/pathology; Radiculopathy/complications; Radiculopathy/pathology; Rats; Rats, Sprague-Dawley; Simplexvirus

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Collection: 01-internacional Database: MEDLINE Main subject: Radiculopathy / Proto-Oncogene Proteins c-bcl-2 / Genetic Vectors / Anterior Horn Cells / Motor Neurons / Nerve Degeneration Limits: Animals / Humans / Male Language: En Journal: Exp Neurol Year: 2001 Document type: Article Affiliation country: United States Country of publication: United States

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