Inhibition of protein phosphatase PP1 in GH3B6, but not in GH3 cells, activates the MEK/ERK/c-fos pathway and the human prolactin promoter, involving the coactivator CPB/p300.

Manfroid, I; Martial, J A; Muller, M

Manfroid, I; Martial, J A; Muller, M.

Affiliation

Manfroid I; Laboratoire de Biologie Moléculaire et de Génie Génétique, Université de Liège, Institut de Chimie B6, B-4000 Sart-Tilman, Belgique.

Mol Endocrinol ; 15(4): 625-37, 2001 Apr.

Article in En | MEDLINE | ID: mdl-11266513

Subject(s)

MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinases/metabolism; Nuclear Proteins/metabolism; Phosphoprotein Phosphatases/antagonists & inhibitors; Prolactin/genetics; Proto-Oncogene Proteins c-fos/genetics; Trans-Activators/metabolism; Animals; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; E1A-Associated p300 Protein; Enzyme Inhibitors/pharmacology; Flavonoids/pharmacology; Humans; Isoenzymes; Mitogen-Activated Protein Kinases/antagonists & inhibitors; Okadaic Acid/pharmacology; Phosphoprotein Phosphatases/genetics; Phosphoprotein Phosphatases/metabolism; Pituitary Neoplasms; Prolactin/metabolism; Promoter Regions, Genetic; Protein Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins c-fos/drug effects; Proto-Oncogene Proteins c-fos/metabolism; Rats; Signal Transduction; Transcription Factor AP-1/genetics; Transcription Factor AP-1/metabolism; Transcription Factor Pit-1; Transcription Factors/genetics; Transcription Factors/metabolism; Transcriptional Activation; Tumor Cells, Cultured; ras Proteins/drug effects; ras Proteins/genetics; ras Proteins/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Prolactin / Nuclear Proteins / Trans-Activators / Proto-Oncogene Proteins c-fos / Phosphoprotein Phosphatases / Mitogen-Activated Protein Kinases / MAP Kinase Kinase Kinase 1 Limits: Animals / Humans Language: En Journal: Mol Endocrinol Journal subject: BIOLOGIA MOLECULAR / ENDOCRINOLOGIA Year: 2001 Document type: Article Affiliation country: Belgium Country of publication: United States

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