Gene therapy of malignant gliomas: a pilot study of vaccination with irradiated autologous glioma and dendritic cells admixed with IL-4 transduced fibroblasts to elicit an immune response.

Okada, H; Pollack, I F; Lieberman, F; Lunsford, L D; Kondziolka, D; Schiff, D; Attanucci, J; Edington, H; Chambers, W; Kalinski, P; Kinzler, D; Whiteside, T; Elder, E; Potter, D

Okada, H; Pollack, I F; Lieberman, F; Lunsford, L D; Kondziolka, D; Schiff, D; Attanucci, J; Edington, H; Chambers, W; Kalinski, P; Kinzler, D; Whiteside, T; Elder, E; Potter, D.

Affiliation

Okada H; Department of Neurological Surgery, University of Pittsburgh Medical Center, PA 15213, USA.

Hum Gene Ther ; 12(5): 575-95, 2001 Mar 20.

Article in En | MEDLINE | ID: mdl-11268289

Subject(s)

Brain Neoplasms/genetics; Brain Neoplasms/therapy; Cancer Vaccines/genetics; Dendritic Cells/metabolism; Fibroblasts/metabolism; Glioma/genetics; Glioma/therapy; Interleukin-4/genetics; Transduction, Genetic; Adolescent; Adult; Aged; Animals; Brain Neoplasms/immunology; Brain Neoplasms/radiotherapy; Cell Division; Cells, Cultured; Cytokines/biosynthesis; Dendritic Cells/immunology; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts/immunology; Flow Cytometry; Glioma/immunology; Glioma/radiotherapy; Humans; Immunohistochemistry; Leukapheresis; Male; Middle Aged; Phenotype; Pilot Projects; Rats; Retroviridae/genetics; T-Lymphocytes, Cytotoxic/metabolism; Treatment Outcome

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Collection: 01-internacional Database: MEDLINE Main subject: Transduction, Genetic / Dendritic Cells / Brain Neoplasms / Interleukin-4 / Cancer Vaccines / Fibroblasts / Glioma Limits: Adolescent / Adult / Aged / Animals / Female / Humans / Male / Middle aged Language: En Journal: Hum Gene Ther Journal subject: GENETICA MEDICA / TERAPEUTICA Year: 2001 Document type: Article Affiliation country: United States

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