Influence of low-dose oral contraceptives, alcohol, and grapefruit on.
Dig Dis Sci
; 46(1): 133-9, 2001 Jan.
Article
in En
| MEDLINE
| ID: mdl-11270777
ABSTRACT
The aminopryine breath test (ABT) measures hepatic reserve in patients with acute and chronic liver disease and gives an assesment of the hepatic function in patients undergoing major liver surgery. Aminopyrine is metabolized by the mixed cytochrome P-450 system, which can be influenced by many foreign compounds and drugs. Whether these foreign compounds and drugs can influence the results of the ABT has seldomly been tested. We studied three groups Healthy female volunteers, either normally menstruating or taking oral contraceptives, were asked to perform a [13C]ABT during the time of the menses and at midcylce. Healthy volunteers were asked to perform a ABT after consuming 30 g of alcohol. Healthy volunteers were asked to perform a ABT after consuming 250 ml of grapefruit juice. The 13C/12C ratio in expired air was measured by gas isotope ratio mass spectrometry.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Beverages
/
Breath Tests
/
Aminopyrine
/
Citrus
/
Contraceptives, Oral, Hormonal
/
Alcoholic Beverages
/
Ethinyl Estradiol
/
Liver Function Tests
Type of study:
Diagnostic_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Dig Dis Sci
Year:
2001
Document type:
Article
Affiliation country:
Belgium