5-HT 3 receptor antagonist ICS 205-930 alters the discriminative effects of ethanol.
Pharmacol Biochem Behav
; 68(1): 163-70, 2001 Jan.
Article
in En
| MEDLINE
| ID: mdl-11274721
ABSTRACT
The ability of a selective 5-hydroxytryptamine (5-HT(3)) receptor antagonist, ICS 205-930 (3-tropanyl-indole-1-carboxylate, tropisetron), to block the discriminative stimulus effects of ethanol was investigated in rats that were trained to discriminate ethanol (1.25 g/kg ip) from saline with food as the reinforcement. Prior administration of ICS 205-930, at the dose of 0.01 mg/kg, significantly decreased ethanol's discriminative stimulus effect at ED(75) dose of ethanol, while higher doses of ICS 205-930 (10 and 17 mg/kg) showed enhancement of ethanol's discriminative effects at ED(0), ED(25), and ED(50) doses of ethanol. Under conditions where ICS 205-930 (10, 17 mg/kg) was tested alone, rats responded exclusively on the saline-appropriate lever. These effects occurred without significantly altering response rates or blood ethanol concentrations. The results suggest that the 5-HT(3) antagonist ICS 205-930 at lower concentration decreases, and at higher concentration enhances the discriminative stimulus effects associated with a lower to moderate dose of ethanol.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Serotonin Antagonists
/
Central Nervous System Depressants
/
Receptors, Serotonin
/
Discrimination, Psychological
/
Ethanol
/
Indoles
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Pharmacol Biochem Behav
Year:
2001
Document type:
Article
Affiliation country:
United States