The binding of oxidized low density lipoprotein (ox-LDL) to ox-LDL receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells through an increased production of superoxide.

Cominacini, L; Rigoni, A; Pasini, A F; Garbin, U; Davoli, A; Campagnola, M; Pastorino, A M; Lo Cascio, V; Sawamura, T

Cominacini, L; Rigoni, A; Pasini, A F; Garbin, U; Davoli, A; Campagnola, M; Pastorino, A M; Lo Cascio, V; Sawamura, T.

Affiliation

Cominacini L; Department of Biomedical and Surgical Sciences, Verona University, 37134 Verona, Italy. comina@medicinad.univr.it

J Biol Chem ; 276(17): 13750-5, 2001 Apr 27.

Article in En | MEDLINE | ID: mdl-11278710

Subject(s)

Imidazolines; Lipoproteins, LDL/metabolism; Nitric Oxide/metabolism; Oxygen/metabolism; Receptors, LDL/metabolism; Superoxides/metabolism; Allopurinol/pharmacology; Animals; Antibodies, Monoclonal/pharmacology; Antioxidants/pharmacology; Aorta/metabolism; Ascorbic Acid/pharmacology; Aspirin/pharmacology; Bradykinin/pharmacology; CHO Cells; Catecholamines/pharmacology; Cattle; Cells, Cultured; Chromans/pharmacology; Cricetinae; Dose-Response Relationship, Drug; Endothelium, Vascular/metabolism; Enzyme Inhibitors/pharmacology; Flow Cytometry; Free Radical Scavengers/pharmacology; Hemostatics/pharmacology; Humans; Mice; Probucol/pharmacology; Protein Binding; Reactive Oxygen Species/metabolism; Receptors, Oxidized LDL; Scavenger Receptors, Class E; Thrombin/pharmacology; Time Factors; omega-N-Methylarginine/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Oxygen / Receptors, LDL / Superoxides / Imidazolines / Lipoproteins, LDL / Nitric Oxide Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2001 Document type: Article Affiliation country: Italy

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