Preliminary report: effect of adrenal androgen and estrogen on bone maturation and bone mineral density.
Metabolism
; 50(4): 377-9, 2001 Apr.
Article
in En
| MEDLINE
| ID: mdl-11288028
ABSTRACT
To clarify the independent physiological roles of adrenal androgen and estrogen on bone growth, we compared the lumbar spine bone mineral density (BMD) in prepubertal girls with virilizing congenital adrenal hyperplasia (CAH) (n = 17) and girls with central precocious puberty (CPP) (n = 18). When BMD was analyzed according to chronologic age, no significant differences were found between CPP and CAH patients. However, when adjusted to bone age, BMD was statistically higher in CAH than in CPP subjects. This finding suggests that adrenal androgen, as well as estrogen, plays an important role in increasing BMD. Adrenal androgen may act on bone not only as androgen, but as estrogen after having been metabolized into an aromatized bone-active compound in peripheral tissues, such as bone and fat. Therefore, adrenal androgen may have a more important role in increasing BMD than previously realized.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bone Development
/
Bone Density
/
Adrenal Glands
/
Estrogens
/
Androgens
Limits:
Child
/
Female
/
Humans
Language:
En
Journal:
Metabolism
Year:
2001
Document type:
Article
Affiliation country:
Japan