Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat.

Kono, H; Rusyn, I; Uesugi, T; Yamashina, S; Connor, H D; Dikalova, A; Mason, R P; Thurman, R G

Kono, H; Rusyn, I; Uesugi, T; Yamashina, S; Connor, H D; Dikalova, A; Mason, R P; Thurman, R G.

Affiliation

Kono H; Laboratory of Hepatobiology and Toxicology, Department of Pharmacology, University of North Carolina, Mary Ellen Jones Bldg., Chapel Hill, NC 27599-7365, USA.

Am J Physiol Gastrointest Liver Physiol ; 280(5): G1005-12, 2001 May.

Article in En | MEDLINE | ID: mdl-11292610

Subject(s)

Enzyme Inhibitors/pharmacology; Hepatitis, Alcoholic/prevention & control; Hepatitis, Alcoholic/physiopathology; Liver/drug effects; NADPH Oxidases/antagonists & inhibitors; Onium Compounds/pharmacology; Animals; Dietary Fats; Enteral Nutrition; Ethanol/toxicity; Ethanol/urine; Gene Expression Regulation/drug effects; Hepatitis, Alcoholic/pathology; Inflammation/pathology; Liver/pathology; Liver/physiopathology; Male; Models, Biological; NF-kappa B/metabolism; Necrosis; Rats; Rats, Wistar; Transcription, Genetic/drug effects; Tumor Necrosis Factor-alpha/genetics

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Onium Compounds / NADPH Oxidases / Enzyme Inhibitors / Hepatitis, Alcoholic / Liver Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Physiol Gastrointest Liver Physiol Journal subject: FISIOLOGIA / GASTROENTEROLOGIA Year: 2001 Document type: Article Affiliation country: United States Country of publication: United States

Search on Google

Add to My VHL

XML

PubMed Links