Fluoride-induced apoptosis in epithelial lung cells involves activation of MAP kinases p38 and possibly JNK.

Thrane, E V; Refsnes, M; Thoresen, G H; Låg, M; Schwarze, P E

Thrane, E V; Refsnes, M; Thoresen, G H; Låg, M; Schwarze, P E.

Affiliation

Thrane EV; Department of Environmental Medicine, National Institute of Public Health, Oslo, Norway.

Toxicol Sci ; 61(1): 83-91, 2001 May.

Article in En | MEDLINE | ID: mdl-11294978

Subject(s)

Apoptosis/drug effects; Epithelial Cells/drug effects; Epithelial Cells/metabolism; JNK Mitogen-Activated Protein Kinases; Lung/cytology; Sodium Fluoride/toxicity; Animals; Antigen-Antibody Complex/immunology; Autoradiography; Cell Division; Cell Line; Cells, Cultured; DNA/analysis; Electrophoresis, Polyacrylamide Gel; Enzyme Activation/drug effects; Enzyme Inhibitors/pharmacology; Flavonoids/antagonists & inhibitors; Flow Cytometry; Humans; Image Processing, Computer-Assisted; Imidazoles/antagonists & inhibitors; Kinetics; Lung/metabolism; MAP Kinase Kinase 4; Male; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors; Mitogen-Activated Protein Kinases/antagonists & inhibitors; Precipitin Tests; Pyridines/antagonists & inhibitors; Rats; Rats, Inbred Strains; Sensitivity and Specificity; Species Specificity; p38 Mitogen-Activated Protein Kinases

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Sodium Fluoride / Apoptosis / JNK Mitogen-Activated Protein Kinases / Epithelial Cells / Lung Type of study: Diagnostic_studies Limits: Animals / Humans / Male Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2001 Document type: Article Affiliation country: Norway Country of publication: United States

Search on Google

Add to My VHL

XML

PubMed Links