Cytochrome P450 metabolites of arachidonic acid but not cyclooxygenase-2 metabolites contribute to the pulmonary vascular hyporeactivity in rats with acute Pseudomonas pneumonia.

Yaghi, A; Webb, C D; Scott, J A; Mehta, S; Bend, J R; McCormack, D G

Yaghi, A; Webb, C D; Scott, J A; Mehta, S; Bend, J R; McCormack, D G.

Affiliation

Yaghi A; The A. C. Burton Vascular Biology Laboratory, London Health Sciences Centre, London, Ontario, Canada.

J Pharmacol Exp Ther ; 297(2): 479-88, 2001 May.

Article in En | MEDLINE | ID: mdl-11303033

Subject(s)

Arachidonic Acid/metabolism; Cytochrome P-450 Enzyme System/metabolism; Isoenzymes/metabolism; Pneumonia, Bacterial/physiopathology; Prostaglandin-Endoperoxide Synthases/metabolism; Pseudomonas Infections/physiopathology; Pulmonary Circulation/physiology; Animals; Cyclooxygenase 2; Heme Oxygenase (Decyclizing)/metabolism; Hydroxyeicosatetraenoic Acids/pharmacology; Lung/drug effects; Lung/metabolism; Male; Microsomes/metabolism; Nitric Oxide/metabolism; Nitric Oxide Synthase/metabolism; Nitric Oxide Synthase Type II; Nitrobenzenes/pharmacology; Pneumonia, Bacterial/metabolism; Prostaglandin Antagonists/pharmacology; Pseudomonas Infections/metabolism; Rats; Rats, Sprague-Dawley; Sulfonamides/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Pseudomonas Infections / Pulmonary Circulation / Arachidonic Acid / Prostaglandin-Endoperoxide Synthases / Pneumonia, Bacterial / Cytochrome P-450 Enzyme System / Isoenzymes Limits: Animals Language: En Journal: J Pharmacol Exp Ther Year: 2001 Document type: Article Affiliation country: Canada Country of publication: United States

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