Synthesis of novel 3'-C-methylene thymidine and 5-methyluridine/cytidine H-phosphonates and phosphonamidites for new backbone modification of oligonucleotides.

An, H; Wang, T; Maier, M A; Manoharan, M; Ross, B S; Cook, P D

An, H; Wang, T; Maier, M A; Manoharan, M; Ross, B S; Cook, P D.

Affiliation

An H; Isis Pharmaceuticals, Inc., 2292 Faraday Avenue, Carlsbad, CA 92008, USA. han@isisph.com

J Org Chem ; 66(8): 2789-801, 2001 Apr 20.

Article in En | MEDLINE | ID: mdl-11304203

Subject(s)

Anti-Infective Agents/chemical synthesis; Cytidine/analogs & derivatives; Cytidine/chemical synthesis; Oligonucleotides/chemical synthesis; Thymidine/chemical synthesis; Uridine/analogs & derivatives; Antineoplastic Agents/chemical synthesis; Oligonucleotides, Antisense/chemical synthesis; Organophosphonates; Thymidine/analogs & derivatives; Uridine/chemical synthesis

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Collection: 01-internacional Database: MEDLINE Main subject: Oligonucleotides / Thymidine / Uridine / Cytidine / Anti-Infective Agents Language: En Journal: J Org Chem Year: 2001 Document type: Article Affiliation country: United States Country of publication: United States

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