Non-replication of association between cathepsin D genotype and late onset Alzheimer disease.
Am J Med Genet
; 105(2): 179-82, 2001 Mar 08.
Article
in En
| MEDLINE
| ID: mdl-11304834
ABSTRACT
In two recent studies from Germany, a strong association was found between the allelic variant T of the amino acid substitution encoding polymorphism 224 C/T (A38V) in exon 2 of the cathepsin D gene (CTSD) and late onset Alzheimer disease (AD). Other studies from Europe and the USA revealed ambiguous results. Therefore, we performed an independent association study on CTSD and AD in a sample of 324 Caucasian patients from Germany, Switzerland, and Italy with late onset AD, and 302 non-demented controls. We could not confirm an association between CTSD genotype and AD, although there was a slight but not significant increase in frequency of the T allele and T carrier status in AD. Post hoc data analyses suggested that there might be a stronger effect of CTSD genotype on AD risk in males, and an interaction between CTSD and APOE genotypes in males but not females.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cathepsin D
/
Alzheimer Disease
/
Genotype
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Europa
Language:
En
Journal:
Am J Med Genet
Year:
2001
Document type:
Article
Affiliation country:
Germany