Metabolic activation of polycyclic aromatic hydrocarbon trans-dihydrodiols by ubiquitously expressed aldehyde reductase (AKR1A1).

Palackal, N T; Burczynski, M E; Harvey, R G; Penning, T M

Palackal, N T; Burczynski, M E; Harvey, R G; Penning, T M.

Affiliation

Palackal NT; Departments of Biochemistry and Biophysics, and Pharmacology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, 19104-6084, Philadelphia, PA, USA.

Chem Biol Interact ; 130-132(1-3): 815-24, 2001 Jan 30.

Article in En | MEDLINE | ID: mdl-11306097

Subject(s)

Aldehyde Reductase/metabolism; Polycyclic Aromatic Hydrocarbons/metabolism; Aldehyde Reductase/genetics; Biotransformation; Cell Line; Cytochrome P-450 CYP1A1/metabolism; Epoxide Hydrolases/metabolism; Escherichia coli/genetics; Humans; In Vitro Techniques; Oxidation-Reduction; Polycyclic Aromatic Hydrocarbons/chemistry; Polycyclic Aromatic Hydrocarbons/pharmacokinetics; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Stereoisomerism

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Collection: 01-internacional Database: MEDLINE Main subject: Polycyclic Aromatic Hydrocarbons / Aldehyde Reductase Limits: Humans Language: En Journal: Chem Biol Interact Year: 2001 Document type: Article Affiliation country: United States Country of publication: Ireland

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