Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.

Gasparini, L; Gouras, G K; Wang, R; Gross, R S; Beal, M F; Greengard, P; Xu, H

Gasparini, L; Gouras, G K; Wang, R; Gross, R S; Beal, M F; Greengard, P; Xu, H.

Affiliation

Gasparini L; Laboratory of Molecular and Cellular Neuroscience, Fisher Center for Research on Alzheimer Disease, and Laboratory for Mass Spectrometry, The Rockefeller University, New York, New York 10021, USA.

J Neurosci ; 21(8): 2561-70, 2001 Apr 15.

Article in En | MEDLINE | ID: mdl-11306609

Subject(s)

Amyloid beta-Peptides/metabolism; Amyloid beta-Protein Precursor/metabolism; Insulin/metabolism; MAP Kinase Signaling System/physiology; Neurons/metabolism; Alzheimer Disease/metabolism; Animals; Cell Membrane/metabolism; Cells, Cultured; Dose-Response Relationship, Drug; Endoplasmic Reticulum/metabolism; Enzyme Inhibitors/pharmacology; Extracellular Space/metabolism; Golgi Apparatus/metabolism; Insulin/pharmacology; Insulysin; MAP Kinase Signaling System/drug effects; Neurons/cytology; Neurons/drug effects; Peptide Fragments/metabolism; Protein Processing, Post-Translational/drug effects; Protein Processing, Post-Translational/physiology; Protein Transport/drug effects; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Amyloid beta-Peptides / Amyloid beta-Protein Precursor / MAP Kinase Signaling System / Insulin / Neurons Limits: Animals Language: En Journal: J Neurosci Year: 2001 Document type: Article Affiliation country: United States Country of publication: United States

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