Increased bioavailability of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in MRP2-deficient rats.

Dietrich, C G; de Waart, D R; Ottenhoff, R; Schoots, I G; Elferink, R P

Dietrich, C G; de Waart, D R; Ottenhoff, R; Schoots, I G; Elferink, R P.

Affiliation

Dietrich CG; Laboratory of Experimental Hepatology, Department of Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands.

Mol Pharmacol ; 59(5): 974-80, 2001 May.

Article in En | MEDLINE | ID: mdl-11306678

Subject(s)

ATP Binding Cassette Transporter, Subfamily B/metabolism; Carcinogens/pharmacokinetics; Imidazoles/pharmacokinetics; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; ATP Binding Cassette Transporter, Subfamily B/deficiency; ATP Binding Cassette Transporter, Subfamily B/genetics; Administration, Oral; Animals; Biological Availability; Biological Transport; Cells, Cultured; Dogs; Female; Humans; Multidrug Resistance-Associated Protein 2; Rats; Rats, Wistar; Tissue Distribution; Transfection

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Collection: 01-internacional Database: MEDLINE Main subject: Membrane Transport Proteins / Carcinogens / ATP Binding Cassette Transporter, Subfamily B / Multidrug Resistance-Associated Proteins / Imidazoles Limits: Animals / Female / Humans Language: En Journal: Mol Pharmacol Year: 2001 Document type: Article Affiliation country: Netherlands Country of publication: United States

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