Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function.

Liang, X H; Yu, J; Brown, K; Levine, B

Liang, X H; Yu, J; Brown, K; Levine, B.

Affiliation

Liang XH; Department of Medicine, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA.

Cancer Res ; 61(8): 3443-9, 2001 Apr 15.

Article in En | MEDLINE | ID: mdl-11309306

Subject(s)

Autophagy/physiology; Genes, Tumor Suppressor/physiology; Proteins/physiology; Amino Acid Sequence; Animals; Antibiotics, Antineoplastic/pharmacology; Apoptosis Regulatory Proteins; Beclin-1; COS Cells; Cell Nucleus/drug effects; Cell Nucleus/metabolism; Consensus Sequence; Fatty Acids, Unsaturated/pharmacology; Genes, Tumor Suppressor/genetics; Humans; Leucine/genetics; Membrane Proteins; Mutation/physiology; Proteins/genetics; Proteins/metabolism; Sequence Homology, Amino Acid; Signal Transduction/drug effects; Subcellular Fractions/metabolism; Transfection; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Proteins / Genes, Tumor Suppressor Limits: Animals / Humans Language: En Journal: Cancer Res Year: 2001 Document type: Article Affiliation country: United States Country of publication: United States

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