Property-based design: optimization of drug absorption and pharmacokinetics.

van De Waterbeemd, H; Smith, D A; Beaumont, K; Walker, D K

van De Waterbeemd, H; Smith, D A; Beaumont, K; Walker, D K.

Affiliation

van De Waterbeemd H; Department of Drug Metabolism, Pfizer Global Research and Development, Sandwich Laboratories, Sandwich, Kent CT13 9NJ, UK. han_waterbeemd@sandwich.pfizer.com

J Med Chem ; 44(9): 1313-33, 2001 Apr 26.

Article in En | MEDLINE | ID: mdl-11311053

Subject(s)

Drug Design; Pharmaceutical Preparations/metabolism; Pharmacokinetics; Animals; Biological Transport; Blood Proteins/metabolism; Blood-Brain Barrier; Caco-2 Cells; Cell Membrane/metabolism; Eye/metabolism; Humans; Intestinal Absorption; Models, Biological; Models, Molecular; Nasal Mucosa/metabolism; Prodrugs/metabolism; Skin Absorption

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Collection: 01-internacional Database: MEDLINE Main subject: Pharmacokinetics / Pharmaceutical Preparations / Drug Design Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2001 Document type: Article Affiliation country: United kingdom

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