KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel.
Nat Neurosci
; 4(5): 486-91, 2001 May.
Article
in En
| MEDLINE
| ID: mdl-11319556
ABSTRACT
Potassium leak channels are essential to neurophysiological function. Leaks suppress excitability through maintenance of resting membrane potential below the threshold for action potential firing. Conversely, voltage-dependent potassium channels permit excitation because they do not interfere with rise to threshold, and they actively promote recovery and rapid re-firing. Previously attributed to distinct transport pathways, we demonstrate here that phosphorylation of single, native hippocampal and cloned KCNK2 potassium channels produces reversible interconversion between leak and voltage-dependent phenotypes. The findings reveal a pathway for dynamic regulation of excitability.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Potassium
/
Potassium Channels
/
Potassium Channels, Tandem Pore Domain
/
Hippocampus
Limits:
Animals
/
Humans
Language:
En
Journal:
Nat Neurosci
Journal subject:
NEUROLOGIA
Year:
2001
Document type:
Article
Affiliation country:
United States