Apolipoprotein A-I promotes the formation of phosphatidylcholine core aldehydes that are hydrolyzed by paraoxonase (PON-1) during high density lipoprotein oxidation with a peroxynitrite donor.

Ahmed, Z; Ravandi, A; Maguire, G F; Emili, A; Draganov, D; La Du, B N; Kuksis, A; Connelly, P W

Ahmed, Z; Ravandi, A; Maguire, G F; Emili, A; Draganov, D; La Du, B N; Kuksis, A; Connelly, P W.

Affiliation

Ahmed Z; J. Alick Little Lipid Research Laboratory, St. Michael's Hospital, University of Toronto, 38 Shuter Street, Toronto, Ontario M5B 1A6, Canada.

J Biol Chem ; 276(27): 24473-81, 2001 Jul 06.

Article in En | MEDLINE | ID: mdl-11320081

Subject(s)

Aldehydes/metabolism; Apolipoprotein A-I/metabolism; Esterases/metabolism; Lipoproteins, HDL/metabolism; Nitrates/metabolism; Phosphatidylcholines/metabolism; Aryldialkylphosphatase; Electrophoresis, Polyacrylamide Gel; Humans; Hydrolysis; Lysophosphatidylcholines/metabolism; Molsidomine/analogs & derivatives; Molsidomine/metabolism; Oxidation-Reduction; Phospholipases A/metabolism; Proteolipids/metabolism; Trypsin/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Phosphatidylcholines / Apolipoprotein A-I / Aldehydes / Esterases / Lipoproteins, HDL / Nitrates Limits: Humans Language: En Journal: J Biol Chem Year: 2001 Document type: Article Affiliation country: Canada

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