Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis.

Tendler, D S; Bao, C; Wang, T; Huang, E L; Ratovitski, E A; Pardoll, D A; Lowenstein, C J

Tendler, D S; Bao, C; Wang, T; Huang, E L; Ratovitski, E A; Pardoll, D A; Lowenstein, C J.

Affiliation

Tendler DS; Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Cancer Res ; 61(9): 3682-8, 2001 May 01.

Article in En | MEDLINE | ID: mdl-11325839

Subject(s)

Apoptosis/physiology; DNA-Binding Proteins/physiology; Interferon-gamma/physiology; Macrophages/immunology; Nitric Oxide/physiology; Nuclear Proteins/physiology; Phosphoproteins/physiology; Signal Transduction/physiology; Animals; Binding Sites; Cell Hypoxia/physiology; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Enzyme Induction; Female; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Interferon Regulatory Factor-1; Interferon-gamma/pharmacology; Macrophage Activation/physiology; Macrophages/enzymology; Melanoma, Experimental/immunology; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase/biosynthesis; Nitric Oxide Synthase/genetics; Nuclear Proteins/genetics; Nuclear Proteins/metabolism; Phosphoproteins/genetics; Phosphoproteins/metabolism; RNA, Messenger/biosynthesis; RNA, Messenger/genetics; Saccharomyces cerevisiae/genetics; Transcription Factors/physiology; Transcriptional Activation; Transfection

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Collection: 01-internacional Database: MEDLINE Main subject: Phosphoproteins / Nuclear Proteins / Signal Transduction / Interferon-gamma / Apoptosis / DNA-Binding Proteins / Macrophages / Nitric Oxide Limits: Animals Language: En Journal: Cancer Res Year: 2001 Document type: Article Affiliation country: United States Country of publication: United States

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