Expression of the Thomsen-Friedenreich (TF) antigen in the human placenta.
Anticancer Res
; 20(6D): 5129-33, 2000.
Article
in En
| MEDLINE
| ID: mdl-11326683
ABSTRACT
The Thomsen-Friedenreich (TF) antigen (or, more precisely, epitope; Gal beta 1-3GalNAc-) has been known for a long time as a pancarcinoma antigen. Here we report the immunohistochemical identification of this carbohydrate antigen in the human placenta. Paraffin-embedded placental and decidual tissues of the first, second and third trimester were incubated with different monoclonal antibodies (A78-G/A7 and HH8) directed against the TF-epitope and stained with an immunohistochemistry system. We found a strong expression of the TF-epitope in the first trimester of pregnancy. In addition, we identified an expression of the TF-antigen in the second trimester of pregnancy but only in a few cases a positive staining in the third trimester of pregnancy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Placenta
/
Antigens, Tumor-Associated, Carbohydrate
Limits:
Female
/
Humans
Language:
En
Journal:
Anticancer Res
Year:
2000
Document type:
Article
Affiliation country:
Germany