ICOS is critical for CD40-mediated antibody class switching.

McAdam, A J; Greenwald, R J; Levin, M A; Chernova, T; Malenkovich, N; Ling, V; Freeman, G J; Sharpe, A H

McAdam, A J; Greenwald, R J; Levin, M A; Chernova, T; Malenkovich, N; Ling, V; Freeman, G J; Sharpe, A H.

Affiliation

McAdam AJ; Departments of Pathology, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA.

Nature ; 409(6816): 102-5, 2001 Jan 04.

Article in En | MEDLINE | ID: mdl-11343122

Subject(s)

Antigens, Differentiation, T-Lymphocyte/physiology; CD40 Antigens/physiology; Immunoglobulin Class Switching; Animals; Antibody Formation; Antigens, Differentiation, T-Lymphocyte/genetics; B-Lymphocytes/immunology; CD4-Positive T-Lymphocytes/immunology; CD40 Ligand/physiology; Gene Targeting; Germinal Center/physiology; Haptens; Hemocyanins/immunology; Immunoglobulin Isotypes; Inducible T-Cell Co-Stimulator Protein; Mice; T-Lymphocytes/immunology

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Collection: 01-internacional Database: MEDLINE Main subject: Antigens, Differentiation, T-Lymphocyte / Immunoglobulin Class Switching / CD40 Antigens Type of study: Prognostic_studies Limits: Animals Language: En Journal: Nature Year: 2001 Document type: Article Affiliation country: United States Country of publication: United kingdom

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