Attenuation of bleomycin-induced pneumopathy in mice by monoclonal antibody to interleukin-12.

Maeyama, T; Kuwano, K; Kawasaki, M; Kunitake, R; Hagimoto, N; Hara, N

Maeyama, T; Kuwano, K; Kawasaki, M; Kunitake, R; Hagimoto, N; Hara, N.

Affiliation

Maeyama T; Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Higashiku, Fukuoka 812-8582, Japan.

Am J Physiol Lung Cell Mol Physiol ; 280(6): L1128-37, 2001 Jun.

Article in En | MEDLINE | ID: mdl-11350791

Subject(s)

Antibodies, Monoclonal/administration & dosage; Interleukin-12/antagonists & inhibitors; Pulmonary Fibrosis/drug therapy; Animals; Apoptosis/drug effects; Bleomycin; Bronchoalveolar Lavage Fluid/chemistry; Bronchoalveolar Lavage Fluid/cytology; Cell Count; Cytokines/analysis; Cytokines/genetics; Cytokines/metabolism; Disease Models, Animal; Fas Ligand Protein; Hydroxyproline/metabolism; Immunity, Cellular/drug effects; Immunity, Cellular/immunology; Immunohistochemistry; In Situ Nick-End Labeling; Interleukin-12/metabolism; Lung/drug effects; Lung/metabolism; Lung/pathology; Male; Membrane Glycoproteins/genetics; Membrane Glycoproteins/metabolism; Mice; Mice, Inbred C57BL; Pulmonary Fibrosis/chemically induced; Pulmonary Fibrosis/immunology; Pulmonary Fibrosis/pathology; RNA, Messenger/metabolism; Th1 Cells/drug effects; Th1 Cells/immunology; Th1 Cells/metabolism; Th2 Cells/drug effects; Th2 Cells/immunology; Th2 Cells/metabolism; fas Receptor/genetics; fas Receptor/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Pulmonary Fibrosis / Interleukin-12 / Antibodies, Monoclonal Type of study: Prognostic_studies Language: En Journal: Am J Physiol Lung Cell Mol Physiol Journal subject: BIOLOGIA MOLECULAR / FISIOLOGIA Year: 2001 Document type: Article Affiliation country: Japan Country of publication: United States

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