Analysis of epistasis in linked regions in the Irish study of high-density schizophrenia families.
Am J Med Genet
; 105(3): 266-70, 2001 Apr 08.
Article
in En
| MEDLINE
| ID: mdl-11353447
ABSTRACT
Epistasis may be important in the etiology of schizophrenia. Analysis of epistasis has been important in the positional cloning of a gene involved in the etiology of type II diabetes mellitus. We investigated the importance of epistasis among six linked regions in 268 multiplex pedigrees in the Irish Study of High-Density Schizophrenia Families (ISHDSF) by computing pairwise correlations between nonparametric linkage scores for narrow, intermediate, and broad diagnostic definitions. The linked regions were on chromosomes 2, 4, 5, 6, 8, and 10. No correlation reached our a priori level of statistical significance. Using this statistical approach, we did not find evidence of important epistatic effects among these six regions in the ISHDSF.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Schizophrenia
/
Epistasis, Genetic
/
Genetic Linkage
Type of study:
Etiology_studies
/
Prognostic_studies
Limits:
Humans
Country/Region as subject:
Europa
Language:
En
Journal:
Am J Med Genet
Year:
2001
Document type:
Article
Affiliation country:
United States