A polar substituent-containing acylation agent for the radioiodination of internalizing monoclonal antibodies: N-succinimidyl 4-guanidinomethyl-3-[131I]iodobenzoate ([131I]SGMIB).

Vaidyanathan, G; Affleck, D J; Li, J; Welsh, P; Zalutsky, M R

Vaidyanathan, G; Affleck, D J; Li, J; Welsh, P; Zalutsky, M R.

Affiliation

Vaidyanathan G; Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA. ganesan.v@duke.edu

Bioconjug Chem ; 12(3): 428-38, 2001.

Article in En | MEDLINE | ID: mdl-11353542

Subject(s)

Benzoates/chemistry; Guanidine/chemistry; Immunoconjugates/chemistry; Immunoconjugates/pharmacokinetics; Acylation; Antibodies, Monoclonal/chemistry; Antibodies, Monoclonal/metabolism; Benzoates/pharmacokinetics; Biological Transport; ErbB Receptors/immunology; Guanidine/analogs & derivatives; Guanidine/pharmacokinetics; Humans; Immunoconjugates/metabolism; Immunomagnetic Separation; Iodine Radioisotopes/chemistry; Radiopharmaceuticals/chemistry; Radiopharmaceuticals/pharmacokinetics; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Benzoates / Immunoconjugates / Guanidine Limits: Humans Language: En Journal: Bioconjug Chem Journal subject: BIOQUIMICA Year: 2001 Document type: Article Affiliation country: United States Country of publication: United States

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