Glycosidase inhibition by cyclic sulfonium compounds.

Yuasa, H; Takada, J; Hashimoto, H

Yuasa, H; Takada, J; Hashimoto, H.

Affiliation

Yuasa H; Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan. hyuasa@bio.titech.ac.jp

Bioorg Med Chem Lett ; 11(9): 1137-9, 2001 May 07.

Article in En | MEDLINE | ID: mdl-11354361

ABSTRACT

ABSTRACT

Inhibitory activities of various cyclic sulfonium compounds including salacinol against several glycosidases were studied and some compounds showed significant inhibition. The sulfonium ion structure was found to be essential for the inhibitory activity. Specific inhibition of salacinol toward rice alpha-glucosidase was ascribed to the tether arm.

Subject(s)

Enzyme Inhibitors/pharmacology; Glycoside Hydrolases/antagonists & inhibitors; Sulfonium Compounds/pharmacology; Chromatography, High Pressure Liquid; Geobacillus stearothermophilus/enzymology; Magnetic Resonance Spectroscopy; Oryza/enzymology; Saccharomyces cerevisiae/enzymology; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Sulfonium Compounds / Enzyme Inhibitors / Glycoside Hydrolases Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2001 Document type: Article Affiliation country: Japan

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