Protective role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure.

Yamada, K; Ji, J J; Yuan, H; Miki, T; Sato, S; Horimoto, N; Shimizu, T; Seino, S; Inagaki, N

Yamada, K; Ji, J J; Yuan, H; Miki, T; Sato, S; Horimoto, N; Shimizu, T; Seino, S; Inagaki, N.

Affiliation

Yamada K; Department of Physiology, Akita University School of Medicine, Hondo, Akita 010-8543, Japan.

Science ; 292(5521): 1543-6, 2001 May 25.

Article in En | MEDLINE | ID: mdl-11375491

Subject(s)

Adenosine Triphosphate/metabolism; Hypoxia/physiopathology; Neurons/physiology; Potassium Channels, Inwardly Rectifying; Potassium Channels/physiology; Seizures/physiopathology; Substantia Nigra/physiology; Adenosine Triphosphate/pharmacology; Animals; Electroencephalography; Electromyography; Excitatory Amino Acid Antagonists/pharmacology; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Knockout; Patch-Clamp Techniques; Potassium Channels/genetics; Seizures/prevention & control; Substantia Nigra/physiopathology; Synaptic Transmission/drug effects; gamma-Aminobutyric Acid/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Seizures / Substantia Nigra / Potassium Channels / Adenosine Triphosphate / Potassium Channels, Inwardly Rectifying / Hypoxia / Neurons Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Science Year: 2001 Document type: Article Affiliation country: Japan Country of publication: United States

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