Footshock-induced sensitization of the acoustic startle response in two strains of mice.
Behav Brain Res
; 123(1): 17-21, 2001 Aug 27.
Article
in En
| MEDLINE
| ID: mdl-11377726
ABSTRACT
It has been shown before that unconditioned footshocks can augment the acoustic startle response in rats. In the present study, male mice of two strains, C57Bl/6N and BALB/c, were compared with regard to footshock-induced sensitization of the acoustic startle response. Presentation of footshocks did not affect the acoustic startle response in C57Bl/6N mice, while in contrast, footshock-induced sensitization was apparent in the BALB/c strain. Shocked C57Bl/6N mice, but not BALB/c mice, displayed robust conditioning to the startle context when re-tested the next day. These findings indicate that mice may exhibit footshock-induced sensitization of the acoustic startle response, but that the effects of footshocks on the acoustic startle are strain- and time-dependent.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Reflex, Startle
Limits:
Animals
Language:
En
Journal:
Behav Brain Res
Year:
2001
Document type:
Article
Affiliation country:
Netherlands